is Wine with -O3 and -march=native a placebo?

For nerd purposes I've been trying to custom compile Wine to see if i can squeeze some performance out of it, i pulled out the -g flag and put in its place -O3 with march native. i don't know how to benchmark properly to see if there at least a marginal gain, so idk if it is a placebo or not. tried to search for articles in the...